Simplicef is an antibiotic used to treat skin infections (wounds and abscesses) due to susceptible strains of bacteria. Simplicef belongs to a class of drugs called cephalosporins that helps to fight bacteria in the body. Simplicef can be used to treat multiple types of infections such as bronchitis or pneumonia as well as ear, skin, and urinary tract infections. Simplicef is a once-a-day antibiotic tablet. This medicine requires a prescription from your veterinarian and is sold per tablet.