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K9 Advantix ll is the easy way for flea and tick protection, beginning to work within 12 hours and lasting for 30 days. It provides protection against ticks, fleas, mosquitoes, biting flies, and chewing lice.K9 Advantix II kills almost 98-100 % of fleas within 12 hours and continues working for one month to prevent infestations. K9 Advantix ll is waterproof and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight.